Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

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Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

Lu, Yunxia (författare): Imperial College London

Cross, Amanda J (författare): Imperial College London

Murphy, Neil (författare): Imperial College London

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Freisling, Heinz (författare): International Agency for Research on Cancer, World Health Organization

Travis, Ruth C (författare): University of Oxford

Ferrari, Pietro (författare): International Agency for Research on Cancer, World Health Organization

Katzke, Verena A (författare): German Cancer Research Centre,Catalan Institute of Oncology

Kaaks, Rudolf (författare): German Cancer Research Centre

Olsson, Åsa (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital

Johansson, Ingegerd (författare): Umeå University,Umeå universitet,Institutionen för odontologi,Enheten för biobanksforskning

Renström, Frida (författare): Umeå University,Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups

Panico, Salvatore (författare): University of Naples Federico II

Pala, Valeria (författare): Istituto Nazionale dei Tumori

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Peeters, Petra H (författare): Imperial College London,University Medical Center Utrecht

Siersema, Peter D (författare): University Medical Center Utrecht

Bueno-de-Mesquita, H B (författare): National Institute for Public Health and the Environment (RIVM),University of Malaya,University Medical Center Utrecht,Imperial College London

Trichopoulou, Antonia (författare): Academy of Athens,National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Klinaki, Eleni (författare): Hellenic Health Foundation, Athens

Tsironis, Christos (författare): Hellenic Health Foundation, Athens

Agudo, Antonio (författare)

Navarro, Carmen (författare): University of Murcia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council

Sánchez, María-José (författare): University of Granada,CIBER Epidemiology and Public Health (CIBERESP)

Barricarte, Aurelio (författare): CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Boutron-Ruault, Marie-Christine (författare): University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy

Fagherazzi, Guy (författare): Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Racine, Antoine (författare): University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy

Weiderpass, Elisabete (författare): Karolinska Institute,Karolinska Institutet,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center

Gunter, Marc J (författare): Imperial College London

Riboli, Elio (författare): Imperial College London

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(creator_code:org_t)

2016-06-13
2016
Engelska.
Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 27:7, s. 919-927

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BACKGROUND: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC.METHODS: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status.RESULTS: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations.CONCLUSION: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine.IMPACT: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Cancer Causes an ...

Av lärosätet: Umeå universitet; Karolinska Institutet; Lunds universitet

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Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

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